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Project 10: National Preclinical Sepsis Platform

Principal Investigators

Dr. Manoj Lalu| Assistant Professor, University of Ottawa
Contact: mlalu@toh.ca

Dr. Asher Mendelson | Assistant Professor, University of Manitoba 
Contact: Asher.Mendelson@umanitoba.ca

Dr. Braedon McDonald | Assistant Professor, University of Calgary  
Contact: bamcdona@ucalgary.ca

Project Summary

Improving clinical translation of basic science research in sepsis requires innovative methodology combined with “team science” collaborative models. This study establishes a national network of Canadian laboratories to conduct an innovative preclinical multicenter trial of sepsis. Using a multicentric approach, the team will first design standardized models of preclinical sepsis that rigorously evaluate sepsis pathophysiology across multiple biological domains. Second, the team will determine the effects of biological sex on host response in a murine model of sepsis in the context of background antibiotic therapy. Finally, they will identify promising novel sepsis therapeutics and design a pipeline for multicenter preclinical testing.  

If you would like to collaborate on this research project or learn more about it, please contact the Principal Investigators.  

Sepsis Canada Team:
Team 3
Project Status:
Active / Ongoing
Focus Area:
Understanding the causes of sepsis, Improving the management of sepsis