Project Summary

Improving clinical translation of basic science research in sepsis requires innovative methodology combined with “team science” collaborative models. This study establishes a national network of Canadian laboratories to conduct an innovative preclinical multicenter trial of sepsis. Using a multicentric approach, the team will first design standardized models of preclinical sepsis that rigorously evaluate sepsis pathophysiology across multiple biological domains. Second, the team will determine the effects of biological sex on host response in a murine model of sepsis in the context of background antibiotic therapy. Finally, they will identify promising novel sepsis therapeutics and design a pipeline for multicenter preclinical testing.  

If you would like to collaborate on this research project or learn more about it, please contact the Principal Investigators.

Publications

• Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
• National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research
• The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis
• Patient engagement in preclinical laboratory research: A scoping review
• On the same page? A qualitative study protocol on collaboration in a multi-laboratory preclinical study
• Sepsis and obesity: a scoping review of diet-induced obesity murine models
• Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol
• Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions
• Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study