Project Summary

This completed project used population health methods and large, linked datasets to explore the complex interactions between diabetes and sepsis. By considering factors such as predisposing conditions, infection type, immune response, and patient outcomes, the study provided new insights into how diabetes influences sepsis risk and recovery.

Key findings:

• Preexisting diabetes was associated with a lower risk of all-cause mortality but a higher risk of requiring renal replacement therapy in sepsis patients.
• Diabetic sepsis survivors faced a higher long-term risk of major cardiovascular events compared to non-diabetic survivors.
• Risk factors such as age, diabetes, and sepsis-related conditions (e.g., septic shock, acute kidney injury) increased the likelihood of cardiovascular events following sepsis.

These findings contribute to a better understanding of the long-term impacts of sepsis on diabetic patients and may inform future research, clinical care, and policy decisions.

Publications

• Risk Factors for Major Cardiovascular Events in Adult Sepsis Survivors: A Population-Based Cohort Study*
• Preexisting Diabetes Mellitus and All-Cause Mortality in Adult Patients With Sepsis: A Population-Based Cohort Study